Anthony Martial, Chris Smalling and Phil Jones are among the players that could be absent for Manchester United against Fulham.
The trio will be assessed on Friday, as will centre-back Eric Bailly after Wednesday’s 2-2 draw against Arsenal. Luke Shaw is hoping to return after missing that match with a knock and Ashley Young is back from suspension.
Paul Pogba and Romelu Lukaku will be hoping to return to the starting line-up after being dropped to the bench against the Gunners, but Victor Lindelof (groin) and Alexis Sanchez (hamstring) are out.
“(We are) still waiting for conclusions, still waiting for people like Martial, Smalling, Jones – people with these kind of doubts,” Jose Mourinho said.
“But there is a good spirit and people are putting themselves on the line like Chris did in the last match and Jones did against Southampton (in last weekend’s 2-2 draw).
“That’s important when we have so many matches and problems with some players.”
Meanwhile, Mourinho does not feel he can trust big-money signing Fred until Manchester United finally find a way to defend.
Much was expected of the 25-year-old after becoming the club’s fourth most expensive signing of all-time after arriving from Shakhtar Donetsk in a £52million summer deal.
Manchester City vied with United for Fred’s signature but, like January acquisition Alexis Sanchez, Pep Guardiola’s men may well be thinking they have had a lucky escape.
The Brazil international was not even included in Mourinho’s injury-hit squad for Wednesday’s 2-2 draw with Arsenal and has only made eight starts for a United side who have already conceded 25 goals.
Mourinho said Fred was adapting “step by step” to life in the Premier League and added: “You have other players in other clubs that needed time (to adjust) and you have some of them that play even less than Fred is playing.
“I think when the team is defensively stronger, the horizons for Fred change completely.”
Provisional squad : De Gea, Romero, Grant, Darmian, Dalot, Valencia, Smalling, Bailly, Jones, Rojo, Shaw, Young, Matic, Pereira, Herrera, Pogba, Fellaini, Fred, McTominay, Mata, Lingard, Martial, Rashford, Lukaku